Alanine -Zn(Ii) Complex Via Potentiometric Method And Study Of Its Stability Constant, Thermodynamic Parameters And Antimicrobial Effect

Abstract

The Alanine-Zn(II) complex is a bio-coordination compound formed by the binding of zinc(II) ions with alanine, a non-essential amino acid, displaying potential biological activities and therapeutic applications. This research investigates the complexation behavior of alanine with Zn(II) ions through potentiometric titration methods at three different temperatures (303K, 308K, and 313K) under controlled ionic strength conditions. The stability constants of the Zn(II)-alanine complex were determined using the modified Irving-Rossotti technique. The thermodynamic parameters including Gibbs free energy (ΔG), enthalpy change (ΔH), and entropy change (ΔS) were evaluated to understand the thermodynamic nature and spontaneity of the complexation process. The proton-ligand stability constants (pKa) and metal-ligand stability constants (log K) were calculated at different temperatures to understand the binding strength of the complex. Furthermore, the antimicrobial potential of the synthesized Zn(II)-alanine complex was assessed against selected pathogenic microorganisms using standard protocols to explore its possible therapeutic applications. The complex formation was validated through various physicochemical analyses, and the results indicate the successful formation of stable coordination compounds.