Bio-Inspired Schiff Base Complexes: Green Synthesis And Their Role In Combating Cancer And Infection

Authors

  • Supriya Kumari
  • Kumari Sweta
  • Ambika Jyoti
  • Sunil Kumar

DOI:

https://doi.org/10.63278/mme.v31i1.1833

Abstract

In this research, we seek to understand the green synthesis of Bio-Inspired Schiff base complexes and determine their therapeutic potential. Schiff bases result from the condensation of an aldehyde and an amine and serve as a multifunctional ligand in coordination chemistry. AI and models of machine learning were used to predict the optimal reaction parameters to synthesize the Schiff base by means of benzaldehyde and salicylaldehyde aldehydes with the aniline and ethylenediamine amines. These models also predicted the biological properties of the resulting complexes. The synthesized Schiff base complexes showed strong anticancer (IC50 = 23 μM) and antimicrobial (zone of inhibition = 18 mm) activity that justified the efficiency of the bio-inspired approaches for a sustainable synthesis. This methodology presents the potential of Schiff base complexes as environmentally friendly therapeutic against cancer and infections.

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How to Cite

Kumari, Supriya, Kumari Sweta, Ambika Jyoti, and Sunil Kumar. 2025. “Bio-Inspired Schiff Base Complexes: Green Synthesis And Their Role In Combating Cancer And Infection”. Metallurgical and Materials Engineering 31 (1):835-53. https://doi.org/10.63278/mme.v31i1.1833.

Issue

Vol. 31 No. 1 (2025)

Section

Research

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Copyright (c) 2025 Supriya Kumari, Kumari Sweta, Ambika Jyoti, Sunil Kumar

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