One-Pot MCR of 3,4-dihydropyrimidine-2-(1H)-one Derivatives by Silica Supported Cu-Zn Nanoparticle

Authors

  • Jaywant Adhar Patil
  • Dr. Pushpendra Tiwari
  • Lalit Marathe
  • Pradip Patil

DOI:

https://doi.org/10.63278/mme.vi.1742

Keywords:

Green chemistry, Nano catalyst, Sonochemistry, Selective chemistry, High reusability of catalyst

Abstract

A rapid and environmentally sustainable one-pot MCR for the formation of 3,4-dihydropyrimidine-2-(1H)-one analogues, utilizing a silica-supported Cu-Zn nanocomposite as an efficient catalyst under 40 kHz ultrasound conditions with ethanol as the solvent. This one-pot multicomponent reaction, which integrates aromatic aldehydes, urea, and ethyl acetoacetate, yields remarkable results in a very short time, demonstrating high selectivity. The synthesized silica-supported nano catalyst was thoroughly characterized using SEM-EDX. Various spectroscopic techniques, including 1H NMR, 13C NMR, and mass spectrometry has been to confirm the structural information of formed molecules. This method additional advantages like as operational simplicity and environmentally viable, a nano-stable catalyst with excellent reusability (up to 8-10 cycles), rapid reaction times (<10 min), and the elimination of high-cost purification. Because of these attributes, the used method plays dual role sustainable and cost-effective.

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How to Cite

Patil, Jaywant Adhar, Dr. Pushpendra Tiwari, Lalit Marathe, and Pradip Patil. 2025. “One-Pot MCR of 3,4-Dihydropyrimidine-2-(1H)-One Derivatives by Silica Supported Cu-Zn Nanoparticle”. Metallurgical and Materials Engineering, May, 1542-53. https://doi.org/10.63278/mme.vi.1742.

Issue

Vol. 31 No. 5 (2025)

Section

Research

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Copyright (c) 2025 Jaywant Adhar Patil, Dr. Pushpendra Tiwari, Lalit Marathe, Pradip Patil

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