Effect of Fresh Frozen Plasma Transfusion On International Normalized Ratio
DOI:
https://doi.org/10.63278/mme.vi.1702Keywords:
Fresh Frozen Plasma; reduction of INR levels; impact of pre-INR values; Association.Abstract
Importance: Fresh frozen plasma (FFP) serves as a crucial intervention in managing bleeding, surgical, and elevated international normalized ratio (INR) scenarios within medical settings. This research delves into the relationship between FFP administration and the reduction of INR, with a specific focus on the influence of pre-INR values on this connection.
Objective: The primary aim of this study is to investigate the correlation between the administration of FFP and the subsequent reduction of INR levels, particularly emphasizing the impact of pre-INR values on this association.
Design: This study adopts a retrospective cohort design. Data from 271 patients at King Fahad Medical City were included and analyzed. The investigation is focused on discerning the connection between pre-INR values and the resultant change in INR levels following FFP administration. The data for this study were collected and analyzed between [January 2021–October 2021], with the analysis being conducted in [June 2023].
Setting: The study was conducted at King Fahad Medical City, providing insight into a specialized clinical setting catering to various medical conditions and scenarios requiring FFP interventions.
Participants: The study involved patients with various clinical disorders requiring FFP administration, with eligibility determined based on necessity and sociodemographic characteristics. Consecutive sampling ensured all eligible individuals were included.
Results: A total of 1000 units of FFP were transfused to 271 patients, with 46.5% receiving FFP for surgery, 40.9% for bleeding, and 12.5% for high INR. Median pre-transfusion INRs were 1.25 for surgical, 1.65 for bleeding, and 1.9 for high INR patients. Post-transfusion INRs showed significant decreases, especially in the high INR group. Pearson correlation showed strong positive relationships between pre-transfusion INR and INR improvement (r=0.78 for surgical, r=0.89 for bleeding, r=0.92 for high INR), indicating greater efficacy of FFP at higher pre-transfusion INR levels.
Conclusion: FFP administration effectively reduces INR levels, with the greatest improvement observed in patients with higher pre-transfusion INR values.
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Copyright (c) 2025 Abdulaziz Awad Alharbi, Souda Hameed Albeladi, Ammar Hasan Alsughayir, Raneem O. Salem
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