Exploring Drug Nanocrystals: Comprehensive Insights Into Their Formulation And Characterization

Authors

  • Dr. P Premkumar Professor, Research Guide, Dept. of Pharmaceutics,Saveetha College of Pharmacy, Saveetha Institute of Medical and TechnicalSciences (SIMATS), Saveetha university, Thandalam, Chennai-602105, India
  • Mrs. Jency Abraham Research Scholar,Dept. of Pharmaceutics, Saveetha College of Pharmacy,Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveethauniversity, Thandalam, Chennai-602105, India
  • Mrs. Nikhila M Nair Research Scholar, Dept. of Pharmaceutics, Saveetha College of Pharmacy,Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveethauniversity, Thandalam, Chennai-602105, India

Keywords:

Nano crystals, Solubility, BCS classification, Bioavailability.

Abstract

Poor drug solubility remains a significant barrier to the development of highly potent pharmaceutical agents. Drugs with low solubility often exhibit poor oral bioavailability and inconsistent absorption, a concern particularly relevant to Biopharmaceutical Classification System (BCS) Class II drugs. In this class, the primary limitation to drug absorption is the slow dissolution rate caused by low solubility. Despite their high permeability, these drugs suffer from a limited concentration gradient between the gastrointestinal tract and the bloodstream, ultimately hindering effective drug transport and oral absorption.

Downloads

How to Cite

Premkumar , Dr. P, Mrs. Jency Abraham, and Mrs. Nikhila M Nair. 2025. “Exploring Drug Nanocrystals: Comprehensive Insights Into Their Formulation And Characterization”. Metallurgical and Materials Engineering, May, 161-82. https://metall-mater-eng.com/index.php/home/article/view/1572.

Issue

Vol. 31 No. 5 (2025)

Section

Research

License

Copyright (c) 2025 Dr. P Premkumar , Mrs. Jency Abraham , Mrs. Nikhila M Nair

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

  • Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  • Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  • Authors are permitted and encouraged to post their published articles online (e.g., in institutional repositories or on their website, social networks like ResearchGate or Academia), as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

 

Creative Commons License
Except where otherwise noted, the content on this site is licensed under a Creative Commons Attribution 4.0 International License.