Electroactive Biomaterials: Orchestrating Electrical Cues for Enhanced Osseointegration and Bone Regeneration- A Narrative Review

Authors

  • Parthasarathy Natarajan M.D.S, Associate Professor, Department of Prosthodontics, Sri Ramachandra Dental College & Hospital Chennai, India
  • Selvaraj Jayaraman Professor, Centre of Molecular Medicine and Diagnostics (COMManD), Department of Bio-chemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India
  • Jeemee Patel MDS, Associate Professor, Department of Oral and Maxillofacial surgery, Siddhpur Dental College & Hospital, India
  • Roohi Singh BDS (General Dentist) Panjab University, India
  • E.G. Srichakra BDS (General dentist), Rajiv Gandhi University of Health Sciences Bengaluru, India.
  • Hansini Bhaskaran BDS, Consultant dentist, Private practitioner Chennai, Tamil Nadu, India.

DOI:

https://doi.org/10.63278/1436

Keywords:

Electroactive materials, Osseointegration, Bone regeneration, Bone tissue engineering.

Abstract

Electroactive biomaterials are emerging as a transformative approach to enhance osseointegration and bone regeneration by mimicking the intrinsic electrical microenvironment of native bone. This review synthesizes recent advancements in piezoelectric, conductive, and composite electroactive materials, highlighting their capacity to modulate cellular behavior, promote osteogenesis, and combat implant-associated infections. Studies demonstrate that optimized 3D topographies and nanoarrays on piezoelectric substrates, coupled with conductive polymer coatings and antimicrobial surface modifications, significantly improve bone-implant integration and regeneration. Furthermore, the development of self-powered systems and multifunctional coatings exemplifies the pursuit of autonomous, biomimetic implants. Future directions should focus on integrating smart sensors for real-time feedback, developing biodegradable and self-healing materials, elucidating cellular mechanotransduction mechanisms, and establishing robust clinical translation pathways. By harmonizing electrical stimulation, antibacterial properties, and advanced material design, electroactive biomaterials hold immense promise for revolutionizing orthopedic and dental therapies.

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Published

2025-04-16

How to Cite

Parthasarathy Natarajan, Selvaraj Jayaraman, Jeemee Patel, Roohi Singh, E.G. Srichakra, and Hansini Bhaskaran. 2025. “Electroactive Biomaterials: Orchestrating Electrical Cues for Enhanced Osseointegration and Bone Regeneration- A Narrative Review ”. Metallurgical and Materials Engineering 31 (4):274-79. https://doi.org/10.63278/1436.

Issue

Vol. 31 No. 4 (2025)

Section

Research

License

Copyright (c) 2025 Parthasarathy Natarajan, Selvaraj Jayaraman, Jeemee Patel, Roohi Singh, E.G. Srichakra, Hansini Bhaskaran

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