The Relationship of Melatonin to the Physiological Parameters of Pregnant Women During Period Pregnancy

Hanaa Dakheel Mezaala; Kh. G. Al-Fartosib; Mehdi El Arbi

doi:10.63278/10.63278/mme.v31.1

Authors

Hanaa Dakheel Mezaala General Directorate of Education in Thi-Qar, Thi- Qar, Iraq
Kh. G. Al-Fartosib Marshes Researches Center, University of Thi- Qar, Thi-Qar, Iraq
Mehdi El Arbi Institut Supérieur de Biotechnologie de Sfax, Université de Sfax, Tunis, Tunisia

DOI:

https://doi.org/10.63278/10.63278/mme.v31.1

Keywords:

Melatonin, physiological parameters, pregnant women.

Abstract

In recent times, there has been an explosive expansion in the comprehension of the hormone melatonin, particularly regarding its role in physiology, regulation, and therapeutic applications within various realms of clinical medicine. Melatonin serves as a vital biological agent capable of modulating mitochondrial performance, showcasing anti-inflammatory,antioxidant, and neuroprotective properties, promoting restful slumber, and bolstering the immune system. Moreover, it boasts bioavailability and minimal toxicity, positioning it as a promising candidate for the safe and effective treatment of an array of ailments while safeguarding human well-being. Within this manuscript, we endeavored to explore the significance of melatonin during the nascent stages of human existence, encompassing pregnancy, fetal development, and the newborn phase, through a thorough evaluation of contemporary literature.

References

Lerner, A.B.; Case, J.D.; Takahashi, Y.; Lee, T.H.; Mori, W. Isolation of melatonin, the pineal gland factor that lightens melanocytes. J. Am. Chem. Soc. 1958, 80, 2587.

Back, K.; Tan, D.X.; Reiter, R.J. Melatonin biosynthesis in plants: Multiple pathways catalyze tryptophan to melatonin in the cytoplasm or chloroplasts. J. Pineal Res. 2016, 61, 426–437.

Hardeland, R.; Pandi-Perumal, S.R.; Cardinali, D.P. Melatonin. Int. J. Biochem. Cell Biol. 2006, 38, 313–316.

Hardeland, R.; Tan, D.X.; Reiter, R.J. Kynuramines, metabolites of melatonin and other indoles: The resurrection of an almost forgotten class of biogenic amines. J. Pineal Res. 2009, 47, 109–126.

Slominski, R.M.; Reiter, R.J.; Schlabritz-Loutsevitch, N.; Ostrom, R.S.; Slominski, A.T. Melatonin membrane receptors in peripheral tissues: Distribution and functions. Mol. Cell Endocrinol. 2012, 351, 152–166.

Ekmekcioglu, C. Melatonin receptors in humans: Biological role and clinical relevance. Biomed. Pharmacother. 2006, 60, 97–108.

Ma, H.; Kang, J.; Fan, W.; He, H.; Huang, F. ROR: Nuclear Receptor for Melatonin or Not? Molecules 2021, 26, 2693.

Reiter, R.J.; Mayo, J.C.; Tan, D.X.; Sainz, R.M.; Alatorre-Jimenez, M.; Qin, L. Melatonin as an Antioxidant: Under Promises but over Delivers. J. Pineal Res. 2016, 61, 253–278.

Tordjman, S.; Chokron, S.; Delorme, R.; Charrier, A.; Bellissant, E.; Jaafari, N.; Fougerou, C. Melatonin: Pharmacology, Functions and Therapeutic Benefits. Curr. Neuropharmacol. 2017, 15, 434–443.

Carlomagno, G.; Minini, M.; Tilotta, M.; Unfer, V. From Implantation to Birth: Insight into Molecular Melatonin Functions. Int. J. Mol. Sci. 2018, 19, 2802.

Reiter, R.J.; Tan, D.X.; Korkmaz, A.; Rosales-Corral, S.A. Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology. Hum. Reprod. Update 2014, 20, 293–307.

Lanoix, D.; Guérin, P.; Vaillancourt, C. Placental melatonin production and melatonin receptor expression are altered in preeclampsia: New insights into the role of this hormone in pregnancy. J. Pineal Res. 2012, 53, 417–425. [CrossRef

Landgraf, D.; Achten, C.; Dallmann, F.; Oster, H. Embryonic development and maternal regulation of murine circadian clock function. Chronobiol. Int. 2015, 32, 416–427.

Bulun, S.E. Endometriosis. N. Engl. J. Med. 2009, 360, 268–279.

Nnoaham, K.E.; Hummelshoj, L.; Webster, P.; d’Hooghe, T.; de Cicco Nardone, F.; de Cicco Nardone, C.; Jenkinson, C.; Kennedy, S.H.; Zondervan, K.T.; World Endometriosis Research Foundation Global Study of Women’s Health consortium. Reprint of: Impact of endometriosis on quality of life and work productivity: A multicenter study across ten countries. Fertil. Steril. 2019, 112, e137–e152.

Burney, R.O.; Giudice, L.C. Reprint of: Pathogenesis and pathophysiology of endometriosis. Fertil. Steril. 2019, 112, e153–e161.

Bulun, S.E.; Yilmaz, B.D.; Sison, C.; Miyazaki, K.; Bernardi, L.; Liu, S.; Kohlmeier, A.; Yin, P.; Milad, M.; Wei, J. Endometriosis. Endocr. Rev. 2019, 40, 1048–1079.

Marino, J.L.; Holt, V.L.; Chen, C.; Davis, S. Shift work, hCLOCK T3111C polymorphism, and endometriosis risk. Epidemiology. 2008, 19, 477–484.

Mosher, A.A.; Tsoulis, M.W.; Lim, J.; Tan, C.; Agarwal, S.K.; Leyland, N.A.; Foster, W.G. Melatonin activity and receptor expression in endometrial tissue and endometriosis. Hum. Reprod. 2019, 34, 1215–1224. [Google Scholar] [CrossRef]

You-Lin Tain 1,2,3 and Chien-Ning Hsu 4,5,”Melatonin Use during Pregnancy and Lactation Complicated by Oxidative Stress: Focus on Offspring’s Cardiovascular–Kidney– Metabolic Health in Animal Models “, 2024

Luiz Gustavo de Almeida Chuffa , “Melatonin Promotes Uterine and Placental Health: Potential Molecular Mechanisms “.

Chen, B.H.; Park, J.H.; Lee, Y.L.; Kang, I.J.; Kim, D.W.; Hwang, I.K.; Lee, C.-H.; Yan, B.C.; Kim, Y.-M.; Lee, T.-K.; et al. Melatonin improves vascular cognitive impairment induced by ischemic stroke by remyelination via activation of ERK1/2 signaling and restoration of glutamatergic synapses in the gerbil hippocampus. Biomed. Pharmacother. 2018, 108, 687–697. [CrossRef] [PubMed]

Hu, Y.; Wang, Z.; Pan, S.; Zhang, H.; Fang, M.; Jiang, H.; Zhang, H.; Gao, Z.; Xu, K.; Li, Z.; et al. Melatonin protects against blood-brain barrier damage by inhibiting the TLR4/ NF-κB signaling pathway after LPS treatment in neonatal rats. Oncotarget 2017, 8, 31638–31654. Available online: https://pubmed.ncbi.nlm.nih.gov/28404943 (accessed on 1 October 2022). [CrossRef]

You-Lin Tain 1,2,3 and Chien-Ning Hsu 4,5,*Villapol, S.; Fau, S.; Renolleau, S.; Biran, V.; Charriaut-Marlangue, C.; Baud, O. Melatonin promotes myelination by decreasing white matter inflammation after neonatal stroke.Pediatr. Res.2011, 69, 51–55. Available online: https://pubmed.ncbi.nlm.nih.gov/20856166 (accessed on 1 October 2022). [CrossRef].

Melatonin Use during Pregnancy and Lactation Complicated by Oxidative Stress: Focus on Offspring’s Cardiovascular–Kidney– Metabolic Health in Animal Models.