Female Infertility Associated Depression and Anxiety: A Comprehensive Review
DOI:
https://doi.org/10.63278/10.63278/mme.v31.1Keywords:
Infertility, Depression, Anxiety, Stress, Mental HealthAbstract
Infertility poses significant psychological challenges, particularly for women, leading to increased levels of anxiety and depression. This study systematically explores the multifaceted emotional toll of infertility, reviewing literature that underscores a staggering prevalence of depressive symptoms among infertile women, which can range from 25% to 60%. Societal expectations regarding motherhood compound these feelings of distress, contributing to a heightened psychological burden as compared to men. Emphasizing the complexity of this relationship, findings suggest that the psychological distress experienced by these women can parallel that of individuals confronting chronic illnesses. Coping mechanisms play a crucial role in influencing mental health outcomes; adaptive strategies such as problem-solving and seeking social support yield more favorable results, whereas maladaptive strategies—like self-blame and avoidance—exacerbate emotional turmoil. The study also highlights the biopsychosocial framework in contextualizing the experiences of infertile women, depicting how biological factors, psychological distress, and social stressors intertwine to affect mental health. Long-duration infertility correlates with an intensification of anxiety and depression, signaling the importance of timely assessment and intervention. Additionally, analysis of the impacts of various fertility treatment options, particularly assisted reproductive technologies (ART), reveals that the physical and emotional challenges associated with these treatments contribute significantly to psychological outcomes. Through this examination, the research calls for integrated mental health support as part of infertility treatment protocols, advocating for tailored interventions that address the unique coping styles of women facing infertility. By recognizing the extensive mental health implications of infertility, stakeholders can better prepare to address these psychological challenges, ultimately promoting improved quality of life and emotional well-being for affected individuals. This study serves as a critical resource for healthcare practitioners and policymakers, emphasizing the importance of psychological considerations in infertility management.
References
Gdańska, P., Drozdowicz-Jastrzębska, E., Grzechocińska, B., Radziwoń-Zaleska, M., Węgrzyn, P., & Wielgoś, M. (2017). Anxiety and depression in women undergoing infertility treatment. Ginekologia Polska, 88(2), 109-112. https://doi.org/10.5603/gp.a2017.0019
Kamboj, N., Saraswathy, K., Prasad, S., Babu, N., Puri, M., Sharma, A., … & Mahajan, C. (2023). Women infertility and common mental disorders: a cross-sectional study from north india. Plos One, 18(1), e0280054. https://doi.org/10.1371/journal.pone.0280054
Khalesi, Z. (2024). Anxiety, depression, and stress: a comparative study between couples with male and female infertility. BMC Women S Health, 24(1). https://doi.org/10.1186/s12905-024-03072-5
Kiani, Z., Simbar, M., Hajian, S., & Zayeri, F. (2021). The prevalence of depression symptoms among infertile women: a systematic review and meta-analysis. Fertility Research and Practice, 7(1). https://doi.org/10.1186/s40738-021-00098-3
Lawal, O., Akinyemi, J., Yusuff, J., & Okunlola, M. (2020). Perceived stress, psychological distress and serum anti-müllerian hormone levels among infertile and fertile women in north-central nigeria. Middle East Fertility Society Journal, 25(1). https://doi.org/10.1186/s43043-020-00029-0
Maroufizadeh, S., Navid, B., Omani-Samani, R., & Amini, P. (2019). The effects of depression, anxiety and stress symptoms on the clinical pregnancy rate in women undergoing ivf treatment. BMC Research Notes, 12(1). https://doi.org/10.1186/s13104-019-4294-0
Sefogah, P. (2023). Exploring the psychological experiences of women with infertility in urban ghana: a qualitative study. Postgraduate Medical Journal of Ghana, 12(2), 69-73. https://doi.org/10.60014/pmjg.v12i2.336
Alhassan, A., Ziblim, A., & Muntaka, S. (2014). A survey on depression among infertile women in ghana. BMC Women S Health, 14(1). https://doi.org/10.1186/1472-6874-14-42
Anh, V., Huy, T., Huong, T., Quyen, L., & Dung, T. (2023). Anxiety, depression and some related factors in infertile couples being treated at a provincial reproductive health care center, in the south of vietnam. Bangladesh Journal of Medical Science, 22(2), 360-367. https://doi.org/10.3329/bjms.v22i2.64996
Chaves, C., Canavarro, M., & Moura‐Ramos, M. (2018). The role of dyadic coping on the marital and emotional adjustment of couples with infertility. Family Process, 58(2), 509-523. https://doi.org/10.1111/famp.12364
Cui, Y., Li, D., Zhou, B., Lin, Y., & Zeng, Y. (2020). Mediating role of social support between sleep quality, anxiety and depressive symptoms in chinese women undergoing in vitro fertilization treatment. Sage Open Medicine, 8. https://doi.org/10.1177/2050312120930163
Faramarzi, M., Pasha, H., Esmaelzadeh, S., Jorsarai, G., Mir, M., & Abedi, S. (2013). Is coping strategies predictor of anxiety and depression in couple infertile?. Health, 05(03), 643-649. https://doi.org/10.4236/health.2013.53a085
Gdańska, P., Drozdowicz-Jastrzębska, E., Grzechocińska, B., Radziwoń-Zaleska, M., Węgrzyn, P., & Wielgoś, M. (2017). Anxiety and depression in women undergoing infertility treatment. Ginekologia Polska, 88(2), 109-112. https://doi.org/10.5603/gp.a2017.0019
Kamboj, N., Saraswathy, K., Prasad, S., Babu, N., Puri, M., Sharma, A., … & Mahajan, C. (2023). Women infertility and common mental disorders: a cross-sectional study from north india. Plos One, 18(1), e0280054. https://doi.org/10.1371/journal.pone.0280054
Momayyezi, M., Fallahzadeh, H., Nogyni, Z., Anoosheh, V., & Farzaneh, F. (2019). Waiting anxiety in infertile women referring to yazd infertility center. Zahedan Journal of Research in Medical Sciences, 21(3). https://doi.org/10.5812/zjrms.90877
Mustapha, A. (2015). Psychosocial morbidity in women attending an infertility clinic in northwestern nigeria: ‘its the worst misfortune of a woman’. Journal of Gynecology and Obstetrics, 3(1), 6. https://doi.org/10.11648/j.jgo.20150301.12
Qadir, F., Khalid, A., & Medhin, G. (2015). Social support, marital adjustment, and psychological distress among women with primary infertility in pakistan. Women & Health, 55(4), 432-446. https://doi.org/10.1080/03630242.2015.1022687
Sefogah, P. (2023). Exploring the psychological experiences of women with infertility in urban ghana: a qualitative study. Postgraduate Medical Journal of Ghana, 12(2), 69-73. https://doi.org/10.60014/pmjg.v12i2.336
Singh, K., Kumari, S., Rajshee, K., Sinha, S., & Bharti, G. (2020). Assessment of depression, anxiety and stress among indian infertile couples in a tertiary health care centre in bihar. International Journal of Reproduction Contraception Obstetrics and Gynecology, 9(2), 659. https://doi.org/10.18203/2320-1770.ijrcog20200354
Takaki, J. and Hibino, Y. (2014). Family-related opinions and stressful situations associated with psychological distress in women undergoing infertility treatment. International Journal of Environmental Research and Public Health, 11(9), 9068-9081. https://doi.org/10.3390/ijerph110909068
Ogawa M, Takamatsu K, Horiguchi F. Evaluation of factors associated with the anxiety and depression of female infertility patients. Bio Psycho Soc Med. 2011;5(1):15. doi: 10.1186/1751-0759-5-15. [DOI] [PMC free article] [PubMed] [Google Scholar]
Luk BH, Loke AY. The impact of infertility on the psychological well-being, marital relationships, sexual relationships, and quality of life of couples: A systematic review. J Sex Marital Therapy. 2015;41(6):610–625. doi: 10.1080/0092623X.2014.958789. [DOI] [PubMed] [Google Scholar]
Dooley M, Dineen T, Sarma K, Nolan A. The psychological impact of infertility and fertility treatment on the male partner. Human Fertil. 2014;17(3):203–209. doi: 10.3109/14647273.2014.942390. [DOI] [PubMed] [Google Scholar]
Quality of life and general health of infertile women. Namdar A, Naghizadeh MM, Zamani M, Yaghmaei F, Sameni MH. Health Qual Life Outcomes. 2017;15:139. doi: 10.1186/s12955-017-0712-y. [DOI] [PMC free article] [PubMed] [Google Scholar]
The relationship between stress and infertility. Rooney KL, Domar AD. Dialogues Clin Neurosci. 2018;20:41–47. doi: 10.31887/DCNS.2018.20.1/klrooney. [DOI] [PMC free article] [PubMed] [Google Scholar]
Development of a scale for determining violence against infertile women: a scale development study. Onat G. Reprod Health. 2014;11:18. doi: 10.1186/1742-4755-11-18. [DOI] [PMC free article] [PubMed] [Google Scholar]
Anxiety and depression in women undergoing infertility treatment. Gdańska P, Drozdowicz-Jastrzębska E, Grzechocińska B, Radziwon-Zaleska M, Węgrzyn P, Wielgoś M. Ginekol Pol. 2017;88:109–112. doi: 10.5603/GP.a2017.0019. [DOI] [PubMed] [Google Scholar]
Robinson GE, Stewart DE. The psychological impact of infertility and new reproductive technologies. Harvard Rev Psychiatry. 1996;4(3):168–172. doi: 10.3109/10673229609030541. [DOI] [PubMed] [Google Scholar]
Ramezanzadeh F, Aghssa MM, Abedinia N, Zayeri F, Khanafshar N, Shariat M, et al. A survey of relationship between anxiety, depression and duration of infertility. BMC Women’s Health. 2004;4(1):9. doi: 10.1186/1472-6874-4-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
Kucur Suna K, Ilay G, Aysenur A, Kerem Han G, Eda Ulku U, Pasa U, et al. Effects of infertility etiology and depression on female sexual function. J Sex Marital Therapy. 2015:1–9. doi: 10.1080/0092623X.2015.1010673. [DOI] [PubMed] [Google Scholar]
Al-Homaidan HT. Depression among women with primary infertility attending an infertility clinic in Riyadh, Kingdom of Saudi Arabia: rate, severity, and contributing factors. Int J Health Sci. 2011;5(2):108–115. [PMC free article] [PubMed] [Google Scholar]
Diallo, A. (2024). Exploring the psycho-social burden of infertility: perspectives of infertile couples in cape coast, ghana. Plos One, 19(1), e0297428. https://doi.org/10.1371/journal.pone.0297428
Dube, L., Nkosi-Mafutha, N., Balsom, A., & Gordon, J. (2021). Infertility-related distress and clinical targets for psychotherapy: a qualitative study. BMJ Open, 11(11), e050373. https://doi.org/10.1136/bmjopen-2021-050373
Duberstein, Z., Brunner, J., Panisch, L., Bandyopadhyay, S., Irvine, C., Macri, J., … & O’Connor, T. (2021). The biopsychosocial model and perinatal health care: determinants of perinatal care in a community sample. Frontiers in Psychiatry, 12. https://doi.org/10.3389/fpsyt.2021.746803
Dwihestie, L. (2021). The correlation between coping mechanisms and stress levels in childbearing women with infertility. PJMHS, 15(5), 1326-1329. https://doi.org/10.53350/pjmhs211551326
Garay, S., Sumption, L., Pearson, R., & Roshan, J. (2021). Risk factors for excessive gestational weight gain in a uk population: a biopsychosocial model approach. BMC Pregnancy and Childbirth, 21(1). https://doi.org/10.1186/s12884-020-03519-1
Hassan, S., Zahra, A., Parveen, N., Iqbal, N., Mumtaz, S., & Batool, A. (2022). Quality of infertility care services and emotional health of south asian women. Psychology Research and Behavior Management, Volume 15, 1131-1146. https://doi.org/10.2147/prbm.s357301
Iordăchescu, D., Paica, C., Boca, A., Gică, C., Panaitescu, A., Peltecu, G., … & Gică, N. (2021). Anxiety, difficulties, and coping of infertile women. Healthcare, 9(4), 466. https://doi.org/10.3390/healthcare9040466
Kiani, Z., Simbar, M., Hajian, S., & Zayeri, F. (2021). The prevalence of depression symptoms among infertile women: a systematic review and meta-analysis. Fertility Research and Practice, 7(1). https://doi.org/10.1186/s40738-021-00098-3
Downloads
How to Cite
Issue
Section
License
Copyright (c) 2024 Omaima Anan Omer Hamid, Naseem Durizi K Alrawaili, Basmah Durizi K Alrawaili, Wardah Salem S Alanazi, Fai Suraysih T Alanazi

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their published articles online (e.g., in institutional repositories or on their website, social networks like ResearchGate or Academia), as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
Except where otherwise noted, the content on this site is licensed under a Creative Commons Attribution 4.0 International License.