Awareness and Risk Factors of Diabetic Ketoacidosis among General Population in KSA: A Cross-Sectional Study

Authors

  • Faizah Omar Almahmudi Family Medicine Consultant, Ministry of Health, Jeddah, KSA
  • Reem Mohammed Bashowair Family Medicine Senior Registrar, Bupa CareConnect, Jeddah, KSA
  • Khalid Omair Alshehri Family Medicine Senior Registrar, Ministry of Health, Jeddah, KSA
  • Abdulrhman Mahmoud Alhashme Gastroenterology, Service Doctor, KSMC, Riyadh, KSA
  • Mohammed Hassan Alshaikhi Service Doctor, East Jeddah hospital, Jeddah, KSA
  • Mayada Saleh Altwerqe General practitioner, department of Family Medicine, King Fahad Hospital, Jeddah, KSA
  • Mohammed Hazem Tunsi General practitioner, Emergency medicine, King Fahad General hospital, Jeddah, KSA
  • Eyad Anas Sedayo Medical intern, Ibn Sina National College, Jeddah, KSA
  • Reaam Abdullah Alharbi Medical intern, Ibn Sina National College, Jeddah, KSA
  • Salmeen Salah Binmahfouz Medical intern, Ibn Sina National College, Jeddah, KSA
  • Souzi Abdelaziz Haroun Medical intern, Ibn Sina National College, Jeddah, KSA
  • Rewaa Osama Moussa Medical intern, Ibn Sina National College, Jeddah, KSA
  • Reem Abdullah Alghamdi Medical intern, King Abdulaziz University, Jeddah, KSA
  • Sharifah Eissa Alshalan Nurse Specialist, ministry of health -ahssa branch, KSA
  • Reem Abdualaziz Alanazi Nurse Specialist, ministry of health -ahssa branch, KSA

DOI:

https://doi.org/10.63278/10.63278/mme.v31.1

Abstract

Objective: This research aims to determine Awareness and Risk Factors of Diabetic Ketoacidosis among General Population in KSA.

Methods: his study will employ a cross-sectional design to assess the awareness and risk factors of diabetic ketoacidosis (DKA) among the general population in the Kingdom of Saudi Arabia (KSA). The cross-sectional design is chosen to provide a snapshot of the current levels of awareness and the prevalence of risk factors associated with DKA within the population.

Results: The study included 350 participants. The study included 350 participants. The most frequent weight among them was 86-95 kg (n= 110, 31.4%), followed by 76-85 kg (n= 84, 24%), then 66-75 kg (n=54, 15.4%). The most frequent height among study participants was 171-180 cm (n= 117, 33.4%), followed by 161-170 cm (n= 105, 30%), then 150-160 cm (n=36, 10.3%). The most frequent gender among study participants was female (n= 183, 52.2%) and male (n= 167, 47.7%%). The nationality of the study participants most of them was Saudi (n= 315, 90%) and non-Saudi (n= 35, 10%). The employment of the study participants most of them were employed (n= 118, 33.7%), followed by unemployed (n= 94, 26.8%), then self-employed (n=71, 20.2%), and students (n=67, 19.1%). Participants were asked if they smoking. The most of them was smoke (n= 210, 60%) and non-smoke (n=140, 40%). The participants were asked about general awareness. Diabetic ketoacidosis. The results were an emergency event occurs a complication of diabetes and requires an urgent intervention (n=187, 53.4%), followed by normal physiological changes in response to diabetes (n=79, 22.6%), then a chronic complication of diabetes, which occurs over a long time and doesn’t require an urgent (n=68, 19.4%), and I don’t know (n=16, 4.6%).

Conclusion: The study highlights a high level of awareness and knowledge about colorectal cancer among medical staff in Saudi Arabia. Most participants recommended colorectal cancer screening for their families and friends, emphasizing the importance of early detection and preventive measures in reducing cancer mortality rates. However, there are still barriers such as limited resources and misconceptions that need to be addressed to further improve screening participation rates.

References

Wolfsdorf J, Craig ME, Daneman D, Dunger D, Edge J, Lee WR, et al. Diabetic ketoacidosis. Pediatr Diabetes. 2007;8:28–42.

Al-Rubeaan KA, Aftab SA, Alotaibi MS, Alghamdi AA, Rafiullah MR. Clinico-laboratory characteristics of diabetic ketoacidosis in adults. Eur Rev Med Pharmacol Sci. 2011;15:1202–6.

Seth P, Kaur H, Kaur M. Clinical profile of diabetic ketoacidosis: A prospective study in a tertiary care hospital. J Clin Diagn Res. 2015;9:OC01–4.

Ehrmann D, Kulzer B, Roos T, Haak T, Al-Khatib M, Hermanns N. Risk factors and prevention strategies for diabetic ketoacidosis in people with established type 1 diabetes. Lancet Diabetes Endocrinol. 2020;8:436–46.

Dorin RI, Murata GH, Tzamaloukas AH. Respiratory failure in diabetic ketoacidosis. World J Diabetes. 2015;6:1009–23.

Robert AA, Al-Dawish A, Mujammami M, Dawish MAA. Type 1 diabetes mellitus in Saudi Arabia: A soaring epidemic? Int J Pediatr. 2018;2018:9408370.

Madkhly TM, Mohammed FA, Majrashi HH, Kamili FH, Tawhari RAM, Hudisy AA. Final-year medical students’ awareness and knowledge about DKA: A cross-sectional study from a Saudi University. J Family Med Primary Care. 2020;9:1076–9.

Szypowska A, Ramotowska A, Grzechnik-Gryziak M, Szypowski W, Pasierb A, Piechowiak K. High frequency of diabetic ketoacidosis in children with newly diagnosed type 1 diabetes? J Diabetes Res. 2016;2016:9582793.

Mirsadraee R, Khajedaluee M, Vakili R, Hasanabade A, Saeedrezaee Z. Factors associated with newly diagnosed children with diabetic ketoacidosis. J Pediatr Rev. 2017;5:65–71.

Singh H, Thangaraju P, Kumar S, Aravindan U, Balasubramanian H, Selvan T. Knowledge and awareness of diabetes and diabetic ketoacidosis (DKA) among medical students in a tertiary teaching hospital: An observational study. J Clin Diagn Res. 2014;8:4–6.

Federation I. IDF Diabetes Atlas, 4th Edn. Montreal. CA: International Diabetes Federation. 2009. https://diabetesatlas.org/atlas/fourth-edition/

Kearney T, Dang C. Diabetic and endocrine emergencies. Postgraduate medical journal. 2007;83(976):79–86.

Gosmanov AR, Gosmanova EO, Kitabchi AE. Hyperglycemic Crises: Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar State. In: Feingold KR, Anawalt B, Boyce A, Chrousos G, de Herder WW, Dhatariya K, et al.., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000. [cited 2024 Aug 12]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK279052/

Seth P, Kaur H, Kaur M. Clinical Profile of Diabetic Ketoacidosis: A Prospective Study in a Tertiary Care Hospital. Journal of Clinical and Diagnostic Research : JCDR [Internet]. 2015. Jun [cited 2024 Aug 12];9(6):OC01. Available from: https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4525534/

Misra S, Oliver NS. Diabetic ketoacidosis in adults. BMJ. 2015. Oct 28;351:h5660.

Gibb FW, Teoh WL, Graham J, Lockman KA. Risk of death following admission to a UK hospital with diabetic ketoacidosis. Diabetologia. 2016;59(10):2082–7.

Benoit SR, Zhang Y, Geiss LS, Gregg EW, Albright A. Trends in diabetic ketoacidosis hospitalizations and in-hospital mortality—United States, 2000–2014. Morbidity and Mortality Weekly Report. 2018;67(12):362.

Glaser N, Barnett P, McCaslin I, et al.. Pediatric emergency medicine collaborative research committee of the american academy of pediatrics: risk factors for cerebral edema in children with diabetic ketoacidosis. N Engl J Med 2001;25:264–269.

González Pannia P, Balboa R, Navarro R, et al.. Prevalence of cerebral edema among diabetic ketoacidosis patients. Arch Argent Pediatr 2020;118:332–336.

Hamdy O, Khardori R: Diabetic Ketoacidosis: Practice Essentials, Background, Pathophysiology.

Newton CA, Raskin P. Diabetic ketoacidosis in type 1 and type 2 diabetes mellitus: clinical and biochemical differences. Arch Intern Med 2004;27:1925–1931.

Zargar AH, Wani AI, Masoodi SR, et al.. Causes of mortality in diabetes mellitus: data from a tertiary teaching hospital in India. Postgrad Med J 2009;85:227–232.

Root HF. The use of insulin and the abuse of glucose: in the treatment of diabetic coma. J Am Med Assoc 1945;10:557–564.

Feingold KR, et al.. Diabetic Ketoacidosis, Endotext [Internet]. South Dartmouth: MDText.com, Inc. 2018.

Fleckman AM. Diabetic ketoacidosis. Endocrinol Metab Clin North Am 1993;22:181–207.

Foster DW, McGarry JD. The metabolic derangements and treatment of diabetic ketoacidosis. N Engl J Med 1983:159–169.

Hall JE. Lipid metabolism, Guyton and hall textbook of medical physiology, 13th ed. W B Saunders; 2015.

Rosival V. Pathophysiology of diabetic ketoacidosis. Diabetic Med 2015;32:11.

Chaithongdi N, Subauste JS, Koch CA, et al.. Diagnosis and management of hyperglycemic emergencies. Hormones (Athens) 2011;10:250–260.

Chupin M, Charbonnel B, Chupin F. C-peptide blood levels in keto-acidosis and in hyperosmolar non-ketotic diabetic coma. Acta Diabetol Lat 1981;18:123–128.

Eledrisi MS, Alshanti MS, Shah MF, et al.. Overview of the diagnosis and management of diabetic ketoacidosis. Am J Med Sci 2006;331:243–251.

Barski L, Nevzorov R, Rabaev E, et al.. Diabetic ketoacidosis: clinical characteristics, precipitating factors and outcomes of care. Isr Med Assoc J 2012;14:299–303.

Singh H, Saroch A, Pannu AK, et al.. Clinical and biochemical profile, precipitants and prognostic factors of diabetic ketoacidosis: a retrospective study from a tertiary care center of north India. Diabetes Metab Syndr 2019;13:2357–2360.

Ndebele NFM, Naidoo M. The management of diabetic ketoacidosis at a rural regional hospital in KwaZulu-Natal. Afr J Prim Health Care Fam Med 2018;22:10.

Reichel A, Rietzsch H, Köhler HJ, et al.. Cessation of insulin infusion at night-time during CSII-therapy: comparison of regular human insulin and insulin lispro. Exp Clin Endocrinol Diabetes 1998;106:168–172.

Delaney MF, Zisman A, Kettyle WM. Diabetic ketoacidosis and hyperglycemic hyperosmolar nonketotic syndrome. Endocrinol Metab Clin North Am 2000;29:683–705.

Sacks DB, Bruns DE, Goldstein DE, et al.. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Clin Chem 2002;48:436–472.

Wilson DR, D’Souza L, Sarkar N, et al.. New-onset diabetes and ketoacidosis with atypical antipsychotics. Schizophr Res 2003;59:1–6.

Ananth J, Venkatesh R, Burgoyne K, et al.. Atypical antipsychotic drug use and diabetes. Psychother Psychosom 2002;71:244–254.

Hillman K. Fluid resuscitation in diabetic emergencies-a reappraisal. Intensive Care Med 1987;13:4–8.

Diabetes Canada Clinical Practice Guidelines Expert Committee, Goguen J, Gilbert J. Hyperglycemic Emergencies in Adults. Can J Diabetes 2018;42:109–114.

Kitabchi AE, Nyenwe EA. Hyperglycemic crises in diabetes mellitus: diabetic ketoacidosis and hyperglycemic hyperosmolar state. Endocrinol Metab Clin North Am 2006;35:725–751.

Waldhäusl W, Kleinberger G, Korn A, et al.. Severe hyperglycemia: effects of rehydration on endocrine derangements and blood glucose concentration. Diabetes 1979;28:577–584.

Endocrine society’s clinical practice guideline. (2022). Accessed February 12, 2023. https://www.endocrine.org/news-and-advocacy/news-room/2022/endocrine-societys-clinical-practice-guideline-offers-recommendations

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Published

2024-12-14

How to Cite

Faizah Omar Almahmudi, Reem Mohammed Bashowair, Khalid Omair Alshehri, Abdulrhman Mahmoud Alhashme, Mohammed Hassan Alshaikhi, Mayada Saleh Altwerqe, Mohammed Hazem Tunsi, et al. 2024. “Awareness and Risk Factors of Diabetic Ketoacidosis Among General Population in KSA: A Cross-Sectional Study ”. Metallurgical and Materials Engineering 30 (4):276-85. https://doi.org/10.63278/10.63278/mme.v31.1.

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Research